BIOPRECURSOR PRODRUGS PDF

THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.

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Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production.

Home Help Search Login Register. Sites of Administration Sites of action Cell membrane.

Prodrugs to encourage patient acceptance clindamycin antibacterial PowerPoint Presentation: Oxidative Activation 5, 6 dihydropyridine bioprecursor d.

What the body does to the drug? If you wish to download it, please recommend it to your friends in biopreucrsor social system.

Bioprecursor Prodrugs – ppt video online download

Another example is when prodrugs may not be susceptible to metabolism in the presystemic passing before entering the target cell, but maybe the drug itself is. Understand how a drug candidate can be modified to generate a prodrug 3.

If you wish to download it, please recommend it to your friends in any social system. Prodrugs to prodrug patient acceptance clindamycin antibacterial. Auth with social network: To make this website work, we log user data and share it with processors. Google doesn’t tell me the answer, oddly enough.

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Know some examples of currently used prodrugs. Epinephrine anti-glaucoma dipivefrin esterase PowerPoint Presentation: Happiness for me is largely a matter of digestion -Lin Yutang.

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Examples of Carrier-linked Bipartate Prodrugs 5. Phenyl prldrugs are rapidly cleaved by plasma enzymes although simple carbamates are generally too stable to hydrolysis. Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform.

Know some examples of currently used prodrugs PowerPoint Presentation: Azo reduction prontosil sulfanilamide b. This may be helpful for increasing bioavailability, or also if the drug itself is nonspecific in its action.

My presentations Profile Feedback Log out. If it were nonspecific, then having the drug administered could cause unwanted side effects or toxicity before even reaching its target. In order to view it, please contact the author of the presentation. Automatically changes to Flash or non-Flash embed. Phosphorylation Activation ganciclovir substrate for DNA polymerase 5.

Disulfide reduction thiamin tetrahydrofurfuryl disulfide thiamin 3. Feedback Privacy Policy Feedback. Disposition of Chemical Compounds. Download ppt “Bioprecursor Prodrugs”. However, activated amides or amides of amino acids are more susceptible to enzyme mediated cleavage. N-Oxidation pralidoxime acetylcholine esterase activator e. The presentation is successfully added In Your Favorites.

Presentation Description Prodrugs, medicinal prodgugs. Registration Forgot your password? Examples of Carrier-linked Bipartate Prodrugs 6.

Upload from Desktop Single File Upload. Anti-inflammatory drug Tolmetin has a peak plasma concentration of about 1 hr. WordPress Embed Customize Embed. What the body does to the drug?

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Prodrugs_Lecture |authorSTREAM

About project SlidePlayer Terms of Service. However, enzymes present in the specific cell may create the reactive form.

Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production.

Happiness for me is largely a matter of digestion -Lin Yutang. Identify how prodrugs approach can be used to overcome certain issues with a drug candidate 4.

Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the prdrugs reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Powered by SMF 2. Suggest bioptecursor approach to increase the duration of action of Tolmentin Hint: You do not have the permission to view this presentation.

Examples of Carrier-linked Bipartate Prodrugs rpodrugs. Enzymes prrodrugs not just your run of the mill protein! Cookies help us provide you a better browsing experience. Prodrugs for Site Specificity a.